I raised this issue with the team but ultimately we do not intend to add any logic relating to CSS transformations. We are going to leave that to the developer’s responsibility. I would say that if you need this behavior, you will probably want to extend Scene and AdvancedDynamicTexture with your own classes, where you overwrite the pointerX/pointerY calculations with your own function that accounts for the rotation.
But there is probably an easier way to achieve what you are looking for. Can you share a little bit about what your goals are?
You can always apply a rotation to the ADT’s rootContainer if you just want to rotate the UI: Simple GUI in fullscreen mode | Babylon.js Playground (babylonjs.com)